Mapt^tm1(EGFP)Klt
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1(EGFP)Klt
• Name: microtubule-associated protein tau; targeted mutation 1, Kerry Lee Tucker
• MGI ID: MGI:2670768
• Synonyms: Mapt^tm1(GFP)Klt, tauGFP, tau ko
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1(EGFP)Klt page

Beta-amyloid plaques in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and neurofibrillary tangles in Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66561
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a cassette encoding the EGFP fluorescent marker gene and a neomycin resistance gene. Fusion protein including EGFP was detected by Western blot analysis of homozygous mutant brain lysates. Fluorescent illumination indicated that expression of the reporter gene was similar to that of the endogenous gene. (J:66561)

Disease models

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 19 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:66561 Tucker KL, et al., Neurotrophins are required for nerve growth during development. Nat Neurosci. 2001 Jan;4(1):29-37
• All: 159 reference(s)