Festm1Pag
Targeted Allele Detail
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Symbol: |
Festm1Pag |
Name: |
feline sarcoma oncogene; targeted mutation 1, Peter A Greer |
MGI ID: |
MGI:2670783 |
Synonyms: |
FesKR, fpsK588R, fpsKR |
Gene: |
Fes Location: Chr7:80027504-80037694 bp, - strand Genetic Position: Chr7, 45.65 cM
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Alliance: |
Festm1Pag page
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Allele Type: |
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Targeted (Not Specified) |
Mutation: |
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Nucleotide substitutions
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Mutation details: A dinucleotide substitution was introduced at codon 588 (exon 14), converting the lysine codon to an arginine codon (K588R). While protein was detected at wild-type levels in homozygous mutant mice, the absence of lysine 588, a conserved residue of the kinase subdomain II, resulted in an ablation of catalytic activity. The targeting construct also included neo and tk selection genes in the 3' untranslated region.
(J:84535)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fes Mutation: |
41 strains or lines available
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Original: |
J:84535 Senis Y, et al., Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis. Mol Cell Biol. 1999 Nov;19(11):7436-46 |
All: |
5 reference(s) |
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