Hnf1b^tm3Mya
Targeted Allele Detail

Summary

• Symbol: Hnf1b^tm3Mya
• Name: HNF1 homeobox B; targeted mutation 3, Moshe Yaniv
• MGI ID: MGI:2670936
• Synonyms: Hnf1beta^flox
• Gene: Hnf1b Location: Chr11:83741035-83796743 bp, + strand Genetic Position: Chr11, 51.23 cM
• Alliance: Hnf1b^tm3Mya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75935
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus by homologous recombination. The neomycin selection cassette was deleted in ES cells by transient expression of Cre recombinase, resulting in loxP sites flanking the promoter region, the transcription initiation site, and exon 1 in the final allele. (J:75935)

Expression

In Mice Carrying this Mutation:	20 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf1b Mutation: 16 strains or lines available

References

• Original: J:75935 Coffinier C, et al., Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta. Development. 2002 Apr;129(8):1829-38
• All: 21 reference(s)