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Tkttm1Jpi
Targeted Allele Detail
Summary
Symbol: Tkttm1Jpi
Name: transketolase; targeted mutation 1, Joram Piatigorsky
MGI ID: MGI:2671068
Synonyms: Tkt -/-
Gene: Tkt  Location: Chr14:30271088-30296681 bp, + strand  Genetic Position: Chr14, 18.79 cM, cytoband B1
Alliance: Tkttm1Jpi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78430
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequences including intron 2 and exon 3 were replaced with a neomycin selection cassette. Western blot analysis demonstrated that various tissues of heterozygous mice expressed half the amount of encoded protein, and enzymatic assays demonstrated reductions in enzyme activity in various tissues of heterozygous mice. (J:78430)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tkt Mutation:  43 strains or lines available
References
Original:  J:78430 Xu ZP, et al., Transketolase haploinsufficiency reduces adipose tissue and female fertility in mice. Mol Cell Biol. 2002 Sep;22(17):6142-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory