Tkttm1Jpi
Targeted Allele Detail
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Symbol: |
Tkttm1Jpi |
Name: |
transketolase; targeted mutation 1, Joram Piatigorsky |
MGI ID: |
MGI:2671068 |
Synonyms: |
Tkt -/- |
Gene: |
Tkt Location: Chr14:30271088-30296681 bp, + strand Genetic Position: Chr14, 18.79 cM, cytoband B1
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Alliance: |
Tkttm1Jpi page
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Germline Transmission: |
Earliest citation of germline transmission:
J:78430
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Genomic sequences including intron 2 and exon 3 were replaced with a neomycin selection cassette. Western blot analysis demonstrated that various tissues of heterozygous mice expressed half the amount of encoded protein, and enzymatic assays demonstrated reductions in enzyme activity in various tissues of heterozygous mice.
(J:78430)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tkt Mutation: |
43 strains or lines available
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Original: |
J:78430 Xu ZP, et al., Transketolase haploinsufficiency reduces adipose tissue and female fertility in mice. Mol Cell Biol. 2002 Sep;22(17):6142-7 |
All: |
1 reference(s) |
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