Kcnip2^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Kcnip2^tm1Krc
• Name: Kv channel-interacting protein 2; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:2671134
• Synonyms: KChIP2-
• Gene: Kcnip2 Location: Chr19:45780785-45804948 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband D1
• Alliance: Kcnip2^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76843
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment of the gene that contained exons 4 though 9. Morthern blot analysis of RNA derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:76843)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnip2 Mutation: 28 strains or lines available

References

• Original: J:76843 Kuo HC, et al., A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell. 2001 Dec 14;107(6):801-13
• All: 9 reference(s)