Rdx^tm1Sts
Targeted Allele Detail

Summary

• Symbol: Rdx^tm1Sts
• Name: radixin; targeted mutation 1, Shoichiro Tsukita
• MGI ID: MGI:2671151
• Synonyms: Rdx-
• Gene: Rdx Location: Chr9:51958450-52000038 bp, + strand Genetic Position: Chr9, 28.62 cM
• Alliance: Rdx^tm1Sts page

Stereocilia abnormalities on Rdx^tm1Sts/Rdx^tm1Sts cochlear hair cells of adult and newborn mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77485
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment including exon 3 was replaced with a cassette containing a spice acceptor sie, an internal ribosomal entry site followed by a lacZ gene, and a neomycin selection gene. Western blot analysis of kidney and liver proteins derived from homozygous mice demonstrated that no detectable protein was made from this allele. (J:77485)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdx Mutation: 47 strains or lines available

References

• Original: J:77485 Kikuchi S, et al., Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002 Jul;31(3):320-5
• All: 5 reference(s)