Nr1d1^tm1Schb
Targeted Allele Detail

Summary

• Symbol: Nr1d1^tm1Schb
• Name: nuclear receptor subfamily 1, group D, member 1; targeted mutation 1, Ueli Schibler
• MGI ID: MGI:2671157
• Synonyms: Reverba, Rev-erbalpha -
• Gene: Nr1d1 Location: Chr11:98658758-98666159 bp, - strand Genetic Position: Chr11, 62.66 cM
• Alliance: Nr1d1^tm1Schb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78197
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 2, exons 3 and 4 and part of exon 5 was replaced with an in-frame lacZ gene and a neomycin selection cassette. Northern blot analysis demonstrated that no detectable transcript is expressed from this allele, and Western blot analysis confirmed that no detectable protein is made from this allele. (J:78197)

Expression

In Mice Carrying this Mutation:	104038 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr1d1 Mutation: 42 strains or lines available

References

• Original: J:78197 Preitner N, et al., The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002 Jul 26;110(2):251-60
• All: 23 reference(s)