Mllt1^tm1Thr
Targeted Allele Detail

Summary

• Symbol: Mllt1^tm1Thr
• Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; targeted mutation 1, Terence H Rabbitts
• MGI ID: MGI:2671429
• Gene: Mllt1 Location: Chr17:57199611-57242415 bp, - strand Genetic Position: Chr17, 29.56 cM, cytoband E1.1
• Alliance: Mllt1^tm1Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84518
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Other
• Mutation details: A puromycin-loxP cassette was inserted into intron 1 corresponding to a breakpoint region identified in human leukemia patients with t(11;19). (J:84518)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mllt1 Mutation: 21 strains or lines available

References

• Original: J:84518 Forster A, et al., Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell. 2003 May;3(5):449-58
• All: 3 reference(s)