Aspa^nur7
Chemically induced Allele Detail

Summary

• Symbol: Aspa^nur7
• Name: aspartoacylase; neurological 7
• MGI ID: MGI:2671733
• Synonyms: neurological (nur) 07, nur^m07Jus, small lethargic
• Gene: Aspa Location: Chr11:73195813-73217677 bp, - strand Genetic Position: Chr11, 45.28 cM, cytoband B4
• Alliance: Aspa^nur7 page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Exon 4 contains a point mutation of C to T at position 577 that results in an amino acid substitution of a stop codon for glutamine at position 193 (Q193X). The absence of protein expression was confirmed by western blot on brain extracts. (J:143201)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aspa Mutation: 26 strains or lines available

References

• Original: J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6
• All: 15 reference(s)