Zfp423^nur12
Chemically induced Allele Detail

Summary

• Symbol: Zfp423^nur12
• Name: zinc finger protein 423; neurological 12
• MGI ID: MGI:2671784
• Synonyms: ataxia1, nur^m12Jus
• Gene: Zfp423 Location: Chr8:88388438-88686223 bp, - strand Genetic Position: Chr8, 42.29 cM, cytoband C4
• Alliance: Zfp423^nur12 page

Ataxia and malformation in Zfp423^nur12/Zfp423^nur12 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. A C-to-T transition mutation in the fourth exon results in the introduction of a premature stop codon. Western blot analysis showed that no detectable protein was expressed from this allele. (J:114758)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Zfp423 Mutation: 274 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Cerebellar vermis hypoplasia (J:114758).

References

• Original: J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6
• All: 8 reference(s)