Mc4r^Glu3
Chemically induced Allele Detail

Summary

• Symbol: Mc4r^Glu3
• Name: melanocortin 4 receptor; glucose3
• MGI ID: MGI:2671841
• Synonyms: Fatboy, FB, Glu^m03Jus
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^Glu3 page

Obesity is observed in Mc4r^Glu3/Mc4r^Glu3 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion was identified as a T-to-C transition mutation in codon 194, which results in a isoleucine to threonine change in the encoded protein. (J:116205)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 48 strains or lines available

References

• Original: J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6
• All: 2 reference(s)