Nle1l11Jus1
Chemically induced Allele Detail
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Symbol: |
Nle1l11Jus1 |
Name: |
notchless homolog 1; lethal, Chr 11, Justice 1 |
MGI ID: |
MGI:2671871 |
Synonyms: |
l11Jus01 |
Gene: |
Nle1 Location: Chr11:82791594-82799237 bp, - strand Genetic Position: Chr11, 50.3 cM
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Alliance: |
Nle1l11Jus1 page
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Strain of Origin: |
C57BL/6J
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Project Collection: |
Mutagenesis for Dev. Defects
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Nucleotide substitutions
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Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion is a c.1187T>G transversion mutation (p.I396S change in the encoded protein) in l11Jus1 heterozygotes in exon 10. This non-conservative substitution replaces an aliphatic, hydrophobic amino acid with a polar residue, which likely disrupts functionality. In addition, an endogenous C57BL/6J non-synonymous SNP rs13468707 (c.538A>G transition; p.I180V) is present in exon 6. This is the equivalent of well-documented human SNP rs2820949 and leads to a very conservative amino acid substitution. Thus, l11Jus1 homozygotes harbor two coding changes in this gene: an ENU-induced point mutation and an additional spontaneous missense mutation that is also present in the C57BL/6J parent strain.
(J:193532)
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Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:85113 Kile BT, et al., Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 4;425(6953):81-6 |
All: |
3 reference(s) |
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