Kmt2a^{tm2(MLLT3)Thr}
Targeted Allele Detail

Summary

• Symbol: Kmt2a^{tm2(MLLT3)Thr}
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 2, Terence H Rabbitts
• MGI ID: MGI:2671905
• Synonyms: Mll1^tm2Thr, Mll^af9, Mll-AF9⁺
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^{tm2(MLLT3)Thr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75959
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Kmt2a^{tm2(MLLT3)Thr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MLLT3 (4300)

  Mllt3

  (MGI:1917372)

• Mutation details: Sequence encoding a 3' portion of human MLLT3 extending from nucleotide 1634 to the translation terminus replaced a 3' portion of murine Kmt2a exon 8. A downstream neo cassette was also included in the targeting vector for selection. The resultant fusion product putatively recapitulates the KMT2A(MLL)/MLLT3 protein produced in patients with the acute myeloid leukamia (AML) associated transloaction T(9;11)(p22;q23). (J:75959)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Kmt2a^{tm2(MLLT3)Thr}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:75959 Corral J, et al., An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell. 1996 Jun 14;85(6):853-61
• All: 25 reference(s)