Rbp2^tm1Eli
Targeted Allele Detail

Summary

• Symbol: Rbp2^tm1Eli
• Name: retinol binding protein 2, cellular; targeted mutation 1, Ellen Li
• MGI ID: MGI:2672086
• Synonyms: CRBP II^-, CRBPII^-
• Gene: Rbp2 Location: Chr9:98372590-98391824 bp, + strand Genetic Position: Chr9, 51.37 cM
• Alliance: Rbp2^tm1Eli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of liver and intestinal extracts obtained from homozygous mutant mice. Absence of protein was further confirmed by immunohistochemical staining of the intestinal mucosa. (J:79282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbp2 Mutation: 11 strains or lines available

References

• Original: J:79282 E X, et al., Increased neonatal mortality in mice lacking cellular retinol-binding protein II. J Biol Chem. 2002 Sep 27;277(39):36617-23
• All: 6 reference(s)