Disp1^tm1Pab
Targeted Allele Detail

Summary

• Symbol: Disp1^tm1Pab
• Name: dispatched RND transporter family member 1; targeted mutation 1, Philip A Beachy
• MGI ID: MGI:2672101
• Synonyms: mDispA-
• Gene: Disp1 Location: Chr1:182867830-183003086 bp, - strand Genetic Position: Chr1, Syntenic
• Alliance: Disp1^tm1Pab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79457
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7, the last coding exon, was replaced with a floxed neo cassette inserted by homolgous recombination. The deleted exon encoded 78% of the coding sequence (1193 of 1521 codons), including 11 of the 12 transmembrane domains. (J:79457)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disp1 Mutation: 61 strains or lines available

References

• Original: J:79457 Ma Y, et al., Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched. Cell. 2002 Oct 4;111(1):63
• All: 3 reference(s)