Bcl2l1^tm1Cant
Targeted Allele Detail

Summary

• Symbol: Bcl2l1^tm1Cant
• Name: BCL2-like 1; targeted mutation 1, Harvey Cantor
• MGI ID: MGI:2672833
• Synonyms: Bcl-xgamma^-
• Gene: Bcl2l1 Location: Chr2:152622588-152673648 bp, - strand Genetic Position: Chr2, 75.41 cM, cytoband H1
• Alliance: Bcl2l1^tm1Cant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77507
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 which encodes the carboxy terminal of the gamma isoform was replaced with a single loxP site after a floxed neomycin selection cassette was excised via cre mediated recombination. RT-PCR analysis of homozygous mutant T cells identified transcript encoding the L isoform in the absence of transcript encoding the gamma isoform. (J:77507)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l1 Mutation: 104 strains or lines available

References

• Original: J:77507 Ye Q, et al., T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 1;196(1):87-95
• All: 1 reference(s)