Tg(Thy1-MAPT)183Gotz
Transgene Detail
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Symbol: |
Tg(Thy1-MAPT)183Gotz |
Name: |
transgene insertion 183, Jurgen Gotz |
MGI ID: |
MGI:2672839 |
Synonyms: |
P301L tau, pR5 |
Transgene: |
Tg(Thy1-MAPT)183Gotz Location: unknown
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Alliance: |
Tg(Thy1-MAPT)183Gotz page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-MAPT)183Gotz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MAPT (4137) |
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Mutation details: Sequence encoding the longest human MAPT brain isoform (tau40), consisting of exons 2 and 3 as well as four microtubule-binding repeats, was adjoined to the murine Thy1 promoter. The human MAPT sequence included the P301L point mutation, which is linked to human frontotemporal dementia with parkinsonism. Soluble levels of transgenic protein in the brain were approximately 70% of the endogenous level. Expression levels of transgenic protein were high in the hippocampus, fornix fimbriae, amygdala, spinal cord, and cortex, weaker in brain stem and striatum, and not detectable in the olfactory bulb and cerebellum.
(J:66831)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:66831 Gotz J, et al., Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem. 2001 Jan 5;276(1):529-34 |
All: |
35 reference(s) |
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