Rrm2b^tm1Ynak
Targeted Allele Detail

Summary

• Symbol: Rrm2b^tm1Ynak
• Name: ribonucleotide reductase M2 B (TP53 inducible); targeted mutation 1, Yusuke Nakamura
• MGI ID: MGI:2672883
• Synonyms: Rrm2b^-
• Gene: Rrm2b Location: Chr15:37924196-37961562 bp, - strand Genetic Position: Chr15, 15.1 cM
• Alliance: Rrm2b^tm1Ynak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84841
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.4 kb genomic fragment encompassing exons 3 and 4 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of MEFs derived from homozygous mutant mice. (J:84841)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rrm2b Mutation: 27 strains or lines available

References

• Original: J:84841 Kimura T, et al., Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet. 2003 Aug;34(4):440-5
• All: 2 reference(s)