Adam15^tm1Bbl
Targeted Allele Detail

Summary

• Symbol: Adam15^tm1Bbl
• Name: ADAM metallopeptidase domain 15; targeted mutation 1, Carl P Blobel
• MGI ID: MGI:2672997
• Synonyms: adam15^-
• Gene: Adam15 Location: Chr3:89246947-89257589 bp, - strand Genetic Position: Chr3, 39.07 cM
• Alliance: Adam15^tm1Bbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84800
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which encodes the initiator methionine and the first 27 amino acids, was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by either Western blot analysis of heart extracts or immunohistochemical staining of sections of the descending aorta and subcardinal vein. (J:84800)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam15 Mutation: 37 strains or lines available

References

• Original: J:84800 Horiuchi K, et al., Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol. 2003 Aug;23(16):5614-24
• All: 13 reference(s)