Mcpt4^tm1Mabr
Targeted Allele Detail

Summary

• Symbol: Mcpt4^tm1Mabr
• Name: mast cell protease 4; targeted mutation 1, Magnus Abrink
• MGI ID: MGI:2673094
• Gene: Mcpt4 Location: Chr14:56297201-56299767 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Mcpt4^tm1Mabr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84839
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. (J:84839)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcpt4 Mutation: 16 strains or lines available

References

• Original: J:84839 Tchougounova E, et al., The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J Exp Med. 2003 Aug 4;198(3):423-31
• All: 22 reference(s)