Trim25^tm1Mura
Targeted Allele Detail

Summary

• Symbol: Trim25^tm1Mura
• Name: tripartite motif-containing 25; targeted mutation 1, Masami Muramatsu
• MGI ID: MGI:2673138
• Synonyms: efp -/-
• Gene: Trim25 Location: Chr11:88890202-88911119 bp, + strand Genetic Position: Chr11, 54.34 cM, cytoband C
• Alliance: Trim25^tm1Mura page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77296
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic segment containing exon1, which encodes the translation start site and RING finger domain. Northern blot analysis demonstrated that no detectable transcript was present in uteri of homozygous mice. Western blot analysis of proteins derived from uteri of homozygous mice confirmed that no detectable protein product was made. (J:77296)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trim25 Mutation: 44 strains or lines available

References

• Original: J:77296 Orimo A, et al., Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32
• All: 4 reference(s)