Pctp^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Pctp^tm1Bor
• Name: phosphatidylcholine transfer protein; targeted mutation 1, Piet Borst
• MGI ID: MGI:2673156
• Synonyms: Pc-tp -, Pctp^-
• Gene: Pctp Location: Chr11:89873491-89893720 bp, - strand Genetic Position: Chr11, 54.7 cM
• Alliance: Pctp^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57946
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection gene replaced exons C and D by homologous recombination. Western blot analysis demonstrated that no detectable protein product was made in the cytosol of cells derived from homozygous mice. (J:57946)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pctp Mutation: 15 strains or lines available

References

• Original: J:57946 van Helvoort A, et al., Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11501-6
• All: 13 reference(s)