Npepps^goku
Gene trapped Allele Detail

Summary

• Symbol: Npepps^goku
• Name: aminopeptidase puromycin sensitive; goku
• MGI ID: MGI:2673210
• Synonyms: goku
• Gene: Npepps Location: Chr11:97096668-97171464 bp, - strand Genetic Position: Chr11, 60.95 cM
• Alliance: Npepps^goku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56814
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The mutation in the goku mouse was revealed to be an insertion of a gene trap vector in the Psa gene. Sequencing analysis demonstrated that the fusion site between the Pas gene and the gene trap vector is between nucleotide 526 and 527 of the corresponding mRNA. A reporter lacZ gene contained in the gene trap vector is expressed under the control of the endogenous promoter. (J:56814)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npepps Mutation: 124 strains or lines available

References

• Original: J:56814 Osada T, et al., Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method. J Neurosci. 1999 Jul 15;19(14):6068-78
• All: 3 reference(s)