Gata2^tm1Mym
Targeted Allele Detail

Summary

• Symbol: Gata2^tm1Mym
• Name: GATA binding protein 2; targeted mutation 1, Masayuki Yamamoto
• MGI ID: MGI:2673268
• Synonyms: EII-KI, Gata2^gfp
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^tm1Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84836
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding green fluorescent protein (GFP) was inserted into exon 2, replacing the first coding exon. A loxP site flanked neomycin resistance gene cassette that was included in the initial targeting vector was removed via cre-mediated recombination.The profile of GFP expression was consistent with that of the endogenous expression. (J:84836, J:106045)

Expression

In Mice Carrying this Mutation:

90 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 30 strains or lines available

References

• Original: J:84836 Minegishi N, et al., Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood. 2003 Aug 1;102(3):896-905
• All: 17 reference(s)