Entpd1tm1Djp
Targeted Allele Detail
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| Symbol: |
Entpd1tm1Djp |
| Name: |
ectonucleoside triphosphate diphosphohydrolase 1; targeted mutation 1, David J Pinsky |
| MGI ID: |
MGI:2673318 |
| Synonyms: |
cd39- |
| Gene: |
Entpd1 Location: Chr19:40600810-40730046 bp, + strand Genetic Position: Chr19, 34.25 cM
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| Alliance: |
Entpd1tm1Djp page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:76092
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence encompassing exons 5, 6, and 7 was replaced by PGK-neo inserted by homologous recombination. The deleted region encoded the enzymatically active extracellular portion of the mature protein that included apyrase-conserved regions 2 through 4. Although transcript 3' of the neo insertion was detected in homozygous mutant mice Northern blot analysis, apyrase activity and immunoreactivity were undetected.
(J:76092)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Entpd1 Mutation: |
35 strains or lines available
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| Original: |
J:76092 Pinsky DJ, et al., Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J Clin Invest. 2002 Apr;109(8):1031-40 |
| All: |
6 reference(s) |
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Analysis Tools
