Hmga1^tm1Cha
Targeted Allele Detail

Summary

• Symbol: Hmga1^tm1Cha
• Name: high mobility group AT-hook 1; targeted mutation 1, Kirin Chada
• MGI ID: MGI:2673322
• Synonyms: Hmga1^+/-
• Gene: Hmga1 Location: Chr17:27775471-27782648 bp, + strand Genetic Position: Chr17, 14.5 cM
• Alliance: Hmga1^tm1Cha page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:84851
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Inactivation of this locus precluded germline transmission and therefore mice carrying this allele are chimeras. The coding regions of exons 3 through 6 were replaced with a neomycin selection cassette inserted by homologous recombination. (J:84851)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmga1 Mutation: 23 strains or lines available

References

• Original: J:84851 Liu J, et al., Hmga1 is required for normal sperm development. Mol Reprod Dev. 2003 Sep;66(1):81-9
• All: 1 reference(s)