Aliq1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Aliq1^C57BL/6J
• Name: acute lung injury QTL 1; C57BL/6J
• MGI ID: MGI:2673327
• QTL: Aliq1 Location: unknown Genetic Position: Chr11, cM position of peak correlated region/allele: 54.6 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:56829

QTL analysis of 240 F2 mice derived from matings between C57BL/6J and A/J indicated a peak LOD of 6.8 for Aliq1 at 4 cM distal of D11Mit179. This finding is consistent with previous mapping results reported in J:50331, Prows DR; et al., Nat Genet 1997 Dec; 17(4):471-4.

J:50831

Mean survival time (MST) for mice exposed to ozone was analyzed in inbred strains of mice, The most variation was observed between strains A/J (A) and C57BL/6J (B) with resistance inherited as a dominant trait. Analysis of MST in AXB and BXA recombinant inbred strains (RI) showed a contimuum suggesting that more then one gene was involved in susceptibility. QTL analysis of 38 (AxB)F1 x A offspring identified a susceptibility locus on mouse Chromosome 11 2 cMs distal of D11Mit179. This susceptibility marker was identified as Aliq1.

References

• Original: J:50831 Prows DR, et al., Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice. Nat Genet. 1997 Dec;17(4):471-4
• All: 4 reference(s)