Aliq2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Aliq2^C57BL/6J
• Name: acute lung injury QTL 2; C57BL/6J
• MGI ID: MGI:2673329
• QTL: Aliq2 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50831

Mean survival time (MST) for mice exposed to ozone was analyzed in inbred strains of mice, The most variation was observed between strains A/J (A) and C57BL/6J (B) with resistance inherited as a dominant trait. Analysis of MST in AXB and BXA recombinant inbred strains (RI) showed a contimuum suggesting that more then one gene was involved in susceptibility. QTL analysis of 136 A x (AxB)F1 offspring identified a susceptibility locus on mouse Chromosome 13 2 cMs distal of D13Mit59. This susceptibility marker was identified as Aliq2.

References

• Original: J:50831 Prows DR, et al., Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice. Nat Genet. 1997 Dec;17(4):471-4
• All: 3 reference(s)