Pou3f3^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Pou3f3^tm1Tno
• Name: POU domain, class 3, transcription factor 3; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:2673387
• Synonyms: Brn-1^-
• Gene: Pou3f3 Location: Chr1:42734928-42739370 bp, + strand Genetic Position: Chr1, 21.21 cM
• Alliance: Pou3f3^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84756
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 70% (1.2 kb) of the endogenous coding region was replaced with a neo cassette. Gene product was undetected by Western blot analysis and electrophoresis mobility shift assay of homozygous mutant kidney and brain extracts, respectively. (J:84756)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f3 Mutation: 12 strains or lines available

References

• Original: J:84756 Nakai S, et al., Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development. 2003 Oct;130(19):4751-9
• All: 4 reference(s)