Fancd2^tm1Hou
Targeted Allele Detail

Summary

• Symbol: Fancd2^tm1Hou
• Name: Fanconi anemia, complementation group D2; targeted mutation 1, Scott Houghtaling
• MGI ID: MGI:2673422
• Synonyms: Fancd2^-
• Gene: Fancd2 Location: Chr6:113508643-113573978 bp, + strand Genetic Position: Chr6, 52.78 cM, cytoband E3
• Alliance: Fancd2^tm1Hou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84892
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 220 bp encompassing exons 26 and 27 were replaced with a floxed neo-ura cassette. While RT-PCR analysis of homozygous mutant mice showed transcript lacking the targeted exons, neither normal or mutant protein arising from the detected transcript was detected by Western blot analysis. (J:84892)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fancd2^tm1Hou

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancd2 Mutation: 82 strains or lines available

References

• Original: J:84892 Houghtaling S, et al., Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev. 2003 Aug 15;17(16):2021-35
• All: 32 reference(s)