Pcd8ts1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Pcd8ts1^C57BL/6
• Name: p-glycoprotein positive CD8 T cell subset 1; C57BL/6
• MGI ID: MGI:2673483
• QTL: Pcd8ts1 Location: Chr5:114021753-114021986 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 55.72 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of P-glycoprotein positive CD8 T cells in 8 month old mated mice compared to BALB/c. (J:83220)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with CD8 T cell subset levels, Cd8ts1, mapped to 26 cM (D5Mit79) on mouse Chromosome 5 and a QTL associated with P-glycoprotein positive CD8 T cell subset levels, Pcd8ts1, mapped to 61 cM (D5Mit25) on mouse Chromosome 5 with statistical significance of P<0.05. Cd8ts1 is associated with CD8 T cell levels in 18 month old mated mice. Pcd8ts1 is associated with P-glycoprotein positive CD8 T cell levels in 8 month old mated mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)