Cd4ts5^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Cd4ts5^C57BL/6
• Name: CD4 T cell subset 5; C57BL/6
• MGI ID: MGI:2673496
• QTL: Cd4ts5 Location: Chr12:25352444-25352581 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 9.04 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of CD8 memory cells in 8 month old virgin mice compared to BALB/c. (J:83220)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with CD4 T cell subset levels, Cd4ts5, mapped to 6 cM (D12Mit105) on mouse Chromosome 12 with statistical significance of P<0.05. Cd4ts5 is associated with CD4 T cell levels in 18 month old virgin mice, and is also associated with CD8 memory T cell levels in 8 month old virgin mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)