Pcd4ts2^BALB/c
QTL Variant Detail

Summary

• QTL variant: Pcd4ts2^BALB/c
• Name: p-glycoprotein positive CD4 T cell subset 2; BALB/c
• MGI ID: MGI:2673497
• QTL: Pcd4ts2 Location: Chr13:45210442-45210544 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 21.73 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of P-glycoprotein positive CD4 T cells in 8 month old mated mice compared to C57BL/6. (J:83220)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with P-glycoprotein positive CD4 T cell subsetlevels, Pcd4ts2, mapped to 30 cM (D13Mit64) on mouse Chromosome 13 and a QTL associated with CD4 T cell subset levels, Cd4ts6, mapped to 9 cM (D13Mit57) on mouse Chromosome 13 with statistical significance of P<0.05. Pcd4ts2 is associated with P-glycoprotein positive CD4 T cell levels in 8 month old mated mice. Cd4ts6 is associated with CD4 T cell levels in 18 month old virgin mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)