Pcd4ts3^BALB/c
QTL Variant Detail

Summary

• QTL variant: Pcd4ts3^BALB/c
• Name: p-glycoprotein positive CD4 T cell subset 3; BALB/c
• MGI ID: MGI:2673503
• QTL: Pcd4ts3 Location: Chr16:57593923-57594076 bp Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of P-glycoprotein positive CD4 T cells in 8 month old mated mice compared to C57BL/6. (J:83220)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ot1	Pcd4ts3^BALB/c/?	involves: BALB/c * C3H * C57BL/6 * DBA/2

Phenotypes:

Affected Systems	ot1
show or hide all annotated terms
hematopoietic system	√
abnormal CD4-positive, alpha beta T cell morphology	√
immune system	√
abnormal CD4-positive, alpha beta T cell morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with P-glycoprotein positive CD4 T cell subsetlevels, Pcd4ts3, mapped to 38 cM (D16Mit5) on mouse Chromosome 16 with statistical significance of P<0.05. Cd8ts3 is associated with P-glycoprotein positive CD4 T cell levels in 18 month old virgin mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)