Egfrtm2(EGFR)Wag
Targeted Allele Detail
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Symbol: |
Egfrtm2(EGFR)Wag |
Name: |
epidermal growth factor receptor; targeted mutation 2, Erwin F Wagner |
MGI ID: |
MGI:2673586 |
Synonyms: |
hEGFRKI |
Gene: |
Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
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Alliance: |
Egfrtm2(EGFR)Wag page
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Germline Transmission: |
Earliest citation of germline transmission:
J:84870
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Parent Cell Line: |
GS1 (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Egfrtm2(EGFR)Wag expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
EGFR (1956) |
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Mutation details: Floxed human cDNA encoding EGFR was inserted at the endogenous locus via homologous recombination. A RSV-neo cassette was inserted downstream of the human sequence. While endogenous levels of the human transcript were detected in brain tissue by RNAse protection, hypomorphic expression was observed in bone and epithelial tissue, putatively due to an effect of the downstream neo cassette.
(J:84870)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Egfr Mutation: |
87 strains or lines available
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Original: |
J:84870 Sibilia M, et al., Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development. 2003 Oct;130(19):4515-25 |
All: |
3 reference(s) |
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