Mdm2^tm1.1Mep
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm1.1Mep
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 1.1, Mary Ellen Perry
• MGI ID: MGI:2673928
• Synonyms: mdm2^delta7-9
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm1.1Mep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81065
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Floxed sequence encompassing exons 7 through 9 as well as a puromycin selection cassette was excised from Mdm2^tm1Mep via in vivo cre-mediated recombination. Complementation with a null allele indicated that functional gene product is not produced from this allele. (J:81065)

Expression

In Mice Carrying this Mutation:	76 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:81065 Mendrysa SM, et al., mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Mol Cell Biol. 2003 Jan;23(2):462-72
• All: 4 reference(s)