Gdf3^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Gdf3^tm1Zuk
• Name: growth differentiation factor 3; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:2673981
• Gene: Gdf3 Location: Chr6:122582362-122587046 bp, - strand Genetic Position: Chr6, 57.7 cM
• Alliance: Gdf3^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143083
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with an Pgk1-HPRT cassette. The absence of transcript expression was confirmed by RT-PCR on spleen and white adipose tissue extracts. (J:143083)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf3 Mutation: 40 strains or lines available

References

• Original: J:143083 Shen JJ, et al., Deficiency of Growth Differentiation Factor 3 Protects against Diet-Induced Obesity by Selectively Acting on White Adipose. Mol Endocrinol. 2009 Jan;23(1):113-23
• All: 3 reference(s)