Lrp6^rs
Spontaneous Allele Detail

Summary

• Symbol: Lrp6^rs
• Name: low density lipoprotein receptor-related protein 6; ringelschwanz
• MGI ID: MGI:2673982
• Gene: Lrp6 Location: Chr6:134423439-134543876 bp, - strand Genetic Position: Chr6, 65.37 cM
• Alliance: Lrp6^rs page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This allele contains a missense mutation resulting from a C to T transition at coding nucleotide 2656 producing an amino acid substitution of arginine with tryptophan at codon 886 (p.R886W). (J:93008)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lrp6 Mutation: 95 strains or lines available

References

• Original: J:93008 Kokubu C, et al., Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development. 2004 Nov;131(21):5469-80
• All: 3 reference(s)