Nr6a1^tm3Coo
Targeted Allele Detail

Summary

• Symbol: Nr6a1^tm3Coo
• Name: nuclear receptor subfamily 6, group A, member 1; targeted mutation 3, Austin J Cooney
• MGI ID: MGI:2674000
• Synonyms: GCNF^fl
• Gene: Nr6a1 Location: Chr2:38613381-38816464 bp, - strand Genetic Position: Chr2, 24.42 cM
• Alliance: Nr6a1^tm3Coo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85054
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The exon encoding the DNA-binding domain was flanked by single loxP sites. (J:85054, J:87354)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr6a1 Mutation: 145 strains or lines available

References

• Original: J:85054 Lan ZJ, et al., GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J. 2003 Aug 15;22(16):4070-81
• All: 5 reference(s)