Hint1^tm1Ibw
Targeted Allele Detail

Summary

• Symbol: Hint1^tm1Ibw
• Name: histidine triad nucleotide binding protein 1; targeted mutation 1, I Bernard Weinstein
• MGI ID: MGI:2674018
• Synonyms: PKCI^-
• Gene: Hint1 Location: Chr11:54757209-54761327 bp, + strand Genetic Position: Chr11, 32.13 cM
• Alliance: Hint1^tm1Ibw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.6 kb genomic fragment was replaced with a neomycin selection cassette inserted via homologous recombination. Normal protein was undetected by Western blot analysis of various organs obtained from homozygous mutant mice. (J:84504)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hint1^tm1Ibw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Hint1 Mutation: 25 strains or lines available

References

• Original: J:84504 Su T, et al., Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7824-9
• All: 17 reference(s)