Tlr2^tm1Kir
Targeted Allele Detail

Summary

• Symbol: Tlr2^tm1Kir
• Name: toll-like receptor 2; targeted mutation 1, Carsten J Kirschning
• MGI ID: MGI:2674036
• Synonyms: Ly105, TLR2^-
• Gene: Tlr2 Location: Chr3:83743579-83749045 bp, - strand Genetic Position: Chr3, 37.4 cM
• Alliance: Tlr2^tm1Kir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85323
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the extracellular domain and a portion of the transmembrane domain was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of peritoneal macrophages obtained from homozygous mutant mice. (J:85323, J:130011)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tlr2 Mutation: 60 strains or lines available

References

• Original: J:85323 Wooten RM, et al., Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol. 2002 Jan 1;168(1):348-55
• All: 394 reference(s)