Fancatm1Wong
Targeted Allele Detail
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Symbol: |
Fancatm1Wong |
Name: |
Fanconi anemia, complementation group A; targeted mutation 1, Jasmine C Y Wong |
MGI ID: |
MGI:2674094 |
Synonyms: |
Fancatm1Hsc |
Gene: |
Fanca Location: Chr8:123995039-124045315 bp, - strand Genetic Position: Chr8, 72.1 cM
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Alliance: |
Fancatm1Wong page
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Germline Transmission: |
Earliest citation of germline transmission:
J:85108
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Parent Cell Line: |
TL1/TL-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A portion of exon 1 and all of exons 2 through 6 were replaced with a cassette containing IRES-NLS-lacZ and floxed neo. While transcript containing the targeted exons was undetected, RT-PCR analysis of homozygous mutant mice revealed transcript that included exons 14 through 18. A C-terminal antibody was not available to determine if protein was produced from the detected message.
(J:85108)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fanca Mutation: |
81 strains or lines available
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Original: |
J:85108 Wong JC, et al., Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003 Aug 15;12(16):2063-76 |
All: |
3 reference(s) |
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