Rttn^{Gt(pGT1.8geo)7Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Rttn^{Gt(pGT1.8geo)7Pgr}
• Name: rotatin; gene trap 7, Peter Gruss
• MGI ID: MGI:2674124
• Synonyms: rotatin^GT, XV-53
• Gene: Rttn Location: Chr18:88989914-89149140 bp, + strand Genetic Position: Chr18, 58.93 cM
• Alliance: Rttn^{Gt(pGT1.8geo)7Pgr} page

Mutation origin

• Mutant Cell Line: XV-53
• Germline Transmission: Earliest citation of germline transmission: J:76233
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: IRESbetageo Vector Type: gene trap
• Mutation details: An integration of the gene trap vector occurred such that the splice donor at position 1101 to 1102 of the cDNA becomes fused to the splice acceptor in the vector DNA. A protein consisting of the first 281 amino acids of the Rttn gene fused to the beta-galactosidase/neomycin gene is expressed from this allele. (J:76233)

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rttn Mutation: 99 strains or lines available

Notes

Authors note a phenotypic similarity of this mutation to No turning (nt).

References

• Original: J:47980 Stoykova A, et al., Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system. Dev Dyn. 1998 Jun;212(2):198-213
• All: 2 reference(s)