Foxn1^tw
Spontaneous Allele Detail

Summary

• Symbol: Foxn1^tw
• Name: forkhead box N1; traveling wave
• MGI ID: MGI:2674905
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^tw page

120 day old Foxn1^tw/Foxn1^tw

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: Abnormal splicing of this gene results in the generation of two mutant transcripts. The major splicing product lacks 54 bp at the 5' region of the seventh exon, encoding 18 aa in the putative DNA binding domain (DBD). The minor splice product lacks 34 bp, also at the 5' region of the seventh exon, and includes 33 bp from intron 6, yielding a frameshift mutation upstream of the putative DBD. Mutations in proximity to the splice acceptor and donor sites of the sixth and seventh exons were undetected. (J:85194)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:85194 Suzuki N, et al., Traveling stripes on the skin of a mutant mouse. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9680-5
• All: 1 reference(s)