Rcan1^tm1Fmc
Targeted Allele Detail

Summary

• Symbol: Rcan1^tm1Fmc
• Name: regulator of calcineurin 1; targeted mutation 1, Frank McKeon
• MGI ID: MGI:2674908
• Synonyms: dscr1^-
• Gene: Rcan1 Location: Chr16:92188839-92263057 bp, - strand Genetic Position: Chr16, 53.6 cM
• Alliance: Rcan1^tm1Fmc page

Increased inflammatory leukocyte infiltration in sepsis in Rcan1^tm1Fmc/Rcan1^tm1Fmc heart and lung

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85148
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of CD4⁺ T cells obtained from homozygous mutations. (J:85148)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcan1 Mutation: 26 strains or lines available

References

• Original: J:85148 Ryeom S, et al., The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol. 2003 Sep;4(9):874-81
• All: 12 reference(s)