Bcl10^tm1Swm
Targeted Allele Detail

Summary

• Symbol: Bcl10^tm1Swm
• Name: B cell leukemia/lymphoma 10; targeted mutation 1, Stephan W Morris
• MGI ID: MGI:2674989
• Synonyms: Bcl10^-
• Gene: Bcl10 Location: Chr3:145630017-145640121 bp, + strand Genetic Position: Chr3, 71.03 cM, cytoband H3
• Alliance: Bcl10^tm1Swm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85147
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, which encodes the majority of the CARD domain, was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of whole cell lysates of bone marrow, thymus, lymph node, and spleen obtained from homozygous mutant mice. (J:85147)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl10 Mutation: 16 strains or lines available

References

• Original: J:85147 Xue L, et al., Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol. 2003 Sep;4(9):857-65
• All: 16 reference(s)