Mog^tm1Dpd
Targeted Allele Detail

Summary

• Symbol: Mog^tm1Dpd
• Name: myelin oligodendrocyte glycoprotein; targeted mutation 1, Danielle Pham-Dinh
• MGI ID: MGI:2675017
• Synonyms: MOG^-
• Gene: Mog Location: Chr17:37321635-37334290 bp, - strand Genetic Position: Chr17, 19.16 cM, cytoband C
• Alliance: Mog^tm1Dpd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85155
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing lacZ and neo was inserted into exon 1 seven bp upstream of the start codon. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of homozygous mutant mice. The lacZ expression pattern recapitulated that of the endogenous gene. (J:85155)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mog Mutation: 58 strains or lines available

References

• Original: J:85155 Delarasse C, et al., Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest. 2003 Aug;112(4):544-53
• All: 9 reference(s)