Jak3^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Jak3^tm1Jni
• Name: Janus kinase 3; targeted mutation 1, James N Ihle
• MGI ID: MGI:2675061
• Synonyms: Jak3 -
• Gene: Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Jak3^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29723
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A hygromycin selection gene was inserted into the first coding exon. No encoded protein was detected in extracts derived from spleen, thymus, or bone marrow. (J:29723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak3 Mutation: 84 strains or lines available

References

• Original: J:29723 Nosaka T, et al., Defective lymphoid development in mice lacking Jak3. Science. 1995 Nov 3;270(5237):800-2
• All: 14 reference(s)