Cd69^tm1Naka
Targeted Allele Detail

Summary

• Symbol: Cd69^tm1Naka
• Name: CD69 antigen; targeted mutation 1, Toshinori Nakayama
• MGI ID: MGI:2675144
• Gene: Cd69 Location: Chr6:129244287-129252332 bp, - strand Genetic Position: Chr6, 63.21 cM
• Alliance: Cd69^tm1Naka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84940
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by flow cytometric analysis of activated T cells obtained from homozygous mutant mice. (J:84940)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd69 Mutation: 23 strains or lines available

References

• Original: J:84940 Murata K, et al., CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int Immunol. 2003 Aug;15(8):987-92
• All: 15 reference(s)