Akt1^tm1Hem
Targeted Allele Detail

Summary

• Symbol: Akt1^tm1Hem
• Name: thymoma viral proto-oncogene 1; targeted mutation 1, Brian A Hemmings
• MGI ID: MGI:2675202
• Synonyms: Akt1^-, Pkbalpha^-
• Gene: Akt1 Location: Chr12:112620260-112641266 bp, - strand Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
• Alliance: Akt1^tm1Hem page

Structural abnormalities of E14 Akt1^tm1Hem/Akt1^tm1Hem mouse placenta

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85181
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing lacZ and neo was inserted into exon 1 at the start codon via homologous recombination. The insertion deleted the coding region of exon 1 which encodes 15 N-terminal residues. Endogenous protein was undetected by Western blot analysis of homozygous mutant heart tissue. (J:85181)

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1 Mutation: 34 strains or lines available

References

• Original: J:85181 Yang ZZ, et al., Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem. 2003 Aug 22;278(34):32124-31
• All: 27 reference(s)